Abstract
Two novel pyrimidine derivatives have been synthesized and their structures have been confirmed by IR, 1H NMR and mass spectral data. The dissociation constants of these two compounds; 4-(naphthalen-1-yloxy)-N-(p-tolyl) pyrimidin-2-amine (TP-1) and N-(4-fluoro phenyl)-4-(naphthalen-1-yloxy) pyrimidin-2-amine (FP-1) were studied in methanol/DMF - water (60:40v/v) solvent systems at different temperatures ranging from 25°C to 45°C at a 10°C interval using the Calvin–Bjerrum pH titration method. The results are interpreted in terms of substituent present in the compounds. Furthermore, some thermodynamic parameters such as enthalpy (∆H°), Gibb's free energy (∆G°) and entropy (∆S°) of these dissociations have also been evaluated at different temperatures from dissociation constant data.
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