Abstract
Capillary isotachophoresis was applied to the analysis of a new class of bisphosphonates. By using a commercial isotachophoretic system (Shimadzu IP-3A) with a fused-silica detection capillary in comparison with an LKB Tachophor equipped with a PTFE capillary a six-fold higher sensitivity is obtained. In addition, the time of analysis can be shortened. The developed system is applicable to the analysis of disodium 3-amino-1-hydroxypropylidene-1,1-bisphosphonate pentahydrate (Aredia), the main component of the drug formulation (dry substance for injection). Phosphite and phosphate, which are considered to be its trace level by-products, were determined simultaneously. The relative standard deviation for each compound was about 1%.
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