Abstract
在DU染毒动物模型基础上,采用ICP-MS技术同时测定各组织中铀浓度和235U/238U比值,分析DU在体内的分布和代谢规律;提取纯化肝肾组织中的基因组DNA,ICP-MS检测与DNA结合的DU浓度和235U/238U。以Pt为内标元素,补偿基体效应,组织中铀的检出限为0.0019～0.0981μg/kg;精密度（RSD）为0.92%～2.13%,回收率在100%±10%内。ICP-MS对贫铀气溶胶中235U/238U检测结果与经典的α谱仪检测结果相吻合。DNA样品采用中性溶液稀释,DNA中铀元素检出限为0.0016μg/kg DNA,回收率为98.3%±7.3%。样本测定结果显示,肾脏和骨骼对贫铀的蓄积能力最强,脑组织几乎不受贫铀影响,其它组织的DU蓄积能力介于二者之间。在肾、肝组织中,DU可以与DNA发生结合,与肾DNA结合更持久。组织中235U/238U随染毒铀同位素组成和浓度发生规律性改变。铀浓度与235U/238U均可以作为衡量核素污染类型和程度的敏感指标。
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
