Abstract
A sensitive and specific method is described for the determination of dantrolene, a new skeletal muscle relaxant. Method specificity for dantrolene in the presence of dantrolene-related metabolites is based on a combination of solvent extractions, chromatography, and the fluorescence characteristics of dantrolene. The method is satisfactory for use with plasma, blood, urine, bile, tissues, and feces. Modifications of the dantrolene method are also provided for estimating two dantrolene-related metabolites in biological fluids.
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