Abstract
Oriental Journal of Chemistry is a peer reviewed quarterly research journal of pure and applied chemistry. It publishes standard research papers in almost all thrust areas of current chemistry of academic and commercial importance. It provides a platform for rapid publication of quality research papers, reviews and chemistry letters. Oriental Journal of Chemistry is abstracted and indexed in almost all reputed National and International agencies.
Highlights
Cyproheptadine hydrochloride (CPH), chemically known as 4-(5H-dibenzo [a,d] cyclohepten-5-ylidene)-1-methylpiperidine hydrochloride (I), is an antihistaminic, anticholinergic and antiseretonergic agent
Adanski[21] was, perhaps, the first to report colorimetric method for the assay of CPH in tablets.The titrimetric methods[22] were described for the determination of CPH in pharmaceuticals and the methods were based on the solvent extraction-titration of CPH with two ion association reagents, sodium lauryl sulphate, and tetraphenylborate
In continuation of our work on the spectrophotometric determination of drugs[29], we report newly developed and validated spectrophotometric estimation methods of CPH in bulk and pharmaceutical formulations using triphenyl methane dyes viz., bromothymol blue (BTB), bromocresol green (BCG) and bromocresol purple (BCP)
Summary
Cyproheptadine hydrochloride (CPH), chemically known as 4-(5H-dibenzo [a,d] cyclohepten-5-ylidene)-1-methylpiperidine hydrochloride (I), is an antihistaminic, anticholinergic and antiseretonergic agent. Adanski[21] was, perhaps, the first to report colorimetric method for the assay of CPH in tablets.The titrimetric methods[22] were described for the determination of CPH in pharmaceuticals and the methods were based on the solvent extraction-titration of CPH with two ion association reagents, sodium lauryl sulphate, and tetraphenylborate. A sensitive method[28] based on color development with citric acid-Ac O reagent was described for the estimation of cyproheptadine in pharmaceutical dosage forms. In continuation of our work on the spectrophotometric determination of drugs[29], we report newly developed and validated spectrophotometric estimation methods of CPH in bulk and pharmaceutical formulations using triphenyl methane dyes viz., bromothymol blue (BTB), bromocresol green (BCG) and bromocresol purple (BCP). Other chemicals used in the study such as HCl, Sodium acetate are of AR grade and supplied by Sd Fine Chemicals, Mumbai
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