Abstract
Objective To establish a method for determining the contents of tanshinol and salvianolic acid B,the effective components,in Xiaoshuantongluo capsules by RP-HPLC.Methods This detection was conducted with a column of RP-C 18 (Zorbax Eclipse SB-C18,150 mm × 4.6 mm,5 μ m) by HPLC at 25 ℃.The detected samples were eluted with methanol (A) and 1.0％ (v/v) formic acid (B) as a mobile phase.The flow rate was 1.0 ml· min-1; the detection wavelength was 280 nm,and the sample injection volume was 10 μ 1.Results The average recovery rate was 99.97％ for tanshinol (RSD =0.87％,n =6) and 98.78％ for salvianolic acid B (RSD =0.92％,n =6).Conclusions This method is simple,sensitive,accurate and reproducible,and it is a reliable method for assessing the quality of Xiaoshuantongluo capsules. Key words: Xiaoshuantongluo capsules; Tanshinol; Salvianolic acid B; RP-HPLC
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