Abstract
A sensitive gas chromatography, ammonia chemical ionization mass spectrometry, 15N isotope dilution assay has been developed to measure clonazepam and its 7-amino metabolite in blood or plasma. The method was used to measure both compounds in the blood of one subject administered a single 2-mg dose of clonazepam, and in the plasma of thirteen subjects on a clonazepam oral dosing regimen.
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