Abstract
A simple, reliable, and rapid RP-HPLC method has been developed for the determination of clenbuterol HCl in human serum and pharmaceuticals, in order to carry out drug dissolution studies for clenbuterol tablets. This compound is well separated on a C18 column by using the mobile phase consisting of a mixture of acetonitrile and ion-pair buffer (32:68; v/v) at a flow rate of 1.5 mL/min. Detection was carried out using a UV detector at 244 nm. ephedrine HCl was used as an internal standard. Minimum detection limit obtained was 3.78 ng/mL. This method was applied, without any interferences from the excipients, for the determination of the drug in tablet formulation, human serum, and drug dissolution studies.
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