Abstract
An easy, dependable, and sensitive cholic acid activity experiment was designed based on β‑cyclodextrin-modified carbon dot (β‑CD-CD) nanoprobes with specific host-guest recognizing ability and photoelectron transfer capability. The β‑CD-CD nanoprobes were characterized by infrared, ultraviolet-visible, and fluorescence spectroscopy and transmission electron microscopy. The fluorescence of the probes under optimized conditions linearly responded to cholic acid concentration from 0 to 650 μmol·L-1 with a detection limit of 25 nmol·L-1. The probes also performed well in detecting cholic acid in serum and urine samples with an average recovery rate of 97.1%-103.4%. Thus, this study provides a reliable, rapid, and easy method of cholic acid detection in body fluids that can be potentially applied in medical studies.
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