Abstract
Determination of cell death induced by lovastatin on human colon cell line HT29 using comet assay
Highlights
Apoptosis or programmed cell death is an essential process for elimination of damaged cells
Numerous studies suggest that the exposure of tumor cells to statins can lead to cell death
In this study the neutral comet assay was used for the assessment of the apoptotic effect, and exposure of cells to Anisomycin was considered as the positive control. 68.6% of cells were apoptotic after treatment with 2 μg/mL Anisomycin (Table 1)
Summary
Apoptosis or programmed cell death is an essential process for elimination of damaged cells. Objectives: The aim of this study was to determine the type of cell death induced by lovastatin on human colon tumor cells by using the neutral comet assay and to evaluate the utility of this method for detection of apoptosis. Apoptosis or programmed cell death is a physiological process that is a defined process which plays an important role in development and morphogenesis, homeostasis and elimination of damaged and harmful cells. It results in activation of apoptotic pathways, molecular and cell morphology changes such as DNA fragmentation and formation of apoptotic bodies. Alterations in control of cell death or survival are associated with pathogenesis of a variety of human diseases including cancer and many other chronic diseases
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