Abstract
Bupivacaine (Marcaine, Sensorcaine, Carbostesin) is a local anesthetic of the anilide type. Because of a nonpolar n-butylpipecolic group, bupivacaine is more lipid soluble and thus has a longer duration of action than lidocaine or mepivacaine. Most of the systemic toxic reactions of local anesthetics are correlated with high concentrations of these drugs in plasma. Measurement of plasma levels of bupivacaine is therefore important to detect and prevent toxic risks. Several procedures for quantitating bupivacaine in plasma by gas-liquid chromatography (GLC) have been described in the literature (1–5). This paper describes a high-performance liquid chromatography (HPLC) method to measure bupivacaine in plasma.
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