Abstract
A simple and rapid method for the determination of buflomedil hydrochloride [2′,4′6′-trimethoxy-4-(pyrrolidinyl)butyrophenone hydrochloride] in pharmaceutical formulations by reversed-phase ion-pair high-performance liquid chromatography is described. The sample is dissolved in methanol and 1,3,5-trimethoxybenzene is added as an internal standard. The resulting solution is chromatographed on an octadecylsilane column using ion-pair partition chromatography with lauryl sulphase as the counter ion. A 25-μl injection (containing 3.5 μg of buflomedil hydrochloride) produces a 60% full-scale peak (0.2 a.u.f.s.) at the absorbance maximum (275 nm). The relative standard deviation of the method ranges from 1 to 3%, depending on the particular tablet formulation examined. Excipients present in the preparations do not interfere.
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