Abstract

A method is proposed for the determination of bromine in organic compounds (which may also contain chlorine and iodine) by oxygen-flask combustion of the compound followed by pre-column reaction of bromide with acetanilide and 2-iodosobenzoic acid to form 4-bromoacetanilide which is then chromatographed on an ODS column with a mobile phase of methanol: water, 65:35 v/v, detection at 240 nm, and 4- N-acetylaminotoluene as internal standard. The method is rapid and precise (RSD ≤ 1%), and applicable to a variety of bromine-containing organic compounds; the limit of detection is 0.2 ng of bromine.

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