Abstract
Diethylenetriamine pentaacetic acid (DTPA) is a chelate with a strong affinity for certain metals. Since the yttrium complex of this chelate (Y-DTPA) is very stable, can be readily labeled with radioactive yttrium (Y 90 or Y 91) and is quantitatively excreted by the kidney within 24 hr, this compound was used for renal clearance and space of distribution studies in 7 patients. The renal clearance of Y-DTPA was almost identical to that of inulin in two patients and was 33 per cent higher in a third patient, the ratio of C Y-DTPA/ C Cr ranging from 1·27 to 1·89 in the 5 patients so studied. The Y-DTPA space was studied in 5 patients employing a 4 hr constant infusion and in 3 of these, 8–22 hr infusions were also given. The Y-DTPA space varied from 16·0 to 23·2 per cent of total body weight. Y-DTPA and inulin spaces were determined simultaneously in two patients. The Y-DTPA space was 9 per cent and 27 per cent greater than the inulin space for the 2 patients, respectively. The significance of the results obtained and the applicability of this method for clinical investigation will be discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The International Journal Of Applied Radiation And Isotopes
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
