Abstract
The plasma concentrations of diazepam (Valium, Roche Labs., Nutley, N. J.) and its maior metabolite, N‐desmethyldiazepam, after treatment with 5 mg. oral doses three times a day were investigated in 7 subfects. There was a twofold variation in the steady‐state concentrations between subiects. The plasma half‐lifes of diazepam varied between 26 and 53 hours. A crossover study with an evaluation of the bioavailability of 3 manufacturers' tablet products and a suspension of diazepam was included in the investigation. The tablets gave similar intraindividual plasma levels while the suspension showed lower values during steady state, thereby indicating incomplete absorption.
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