Abstract
In the present investigation, two benzimidazole derivatives, fenbendazole (FBZ) and mebendazole (MBZ) were undertaken for pharmacokinetic study in Labeo rohita. Single oral doses of each FBZ and MBZ at 20mg/kg were administered through feed to L. rohita juveniles. The blood was collected at 0.5, 1, 2, 4, 8, 12, 24, 30, 48, 72, 96 and 120h intervals to determine the presence of parent benzimidazole derivatives concentration using High Performance Liquid Chromatography (HPLC). For FBZ, a maximum concentration (Cmax) of 1.32±0.05μgml−1 was measured at 4h (Tmax), whereas the Cmax for MBZ of 1.66±0.08μgml−1 was detected at 8h (Tmax) and the half-life (t1/2) was calculated as 16h and 27.5h for FBZ and MBZ, respectively. The transaminases enzymes (AST and ALT) activities were significantly higher (p<0.05) in all benzimidazole treatments compared to control. However, the antioxidant enzymes (SOD, catalase and GST) activities were found significantly (p<0.05) higher in MBZ treated group compared to FBZ and control. Thus, the results of present revealed that compared to MBZ, FBZ was absorbed quickly and depleted efficiently providing possible time for proficiently removal of helminths in L. rohita.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
