Abstract
Abstract Techniques for the measurement of amylobarbitone and its pricipal metabolite, 3′-hydroxyamylobarbitone in 100-μl plasma samples are described. The methods which employ a mass spectrometer as a gas chromatographic detector may be used to determine 0.01 μ/ml of the drug and 0.0 μ/ml of the metabolite and were developed initially to permit pharmacodynamic studies in human newborn. With minor modification, they are applicable to other barbiturates including butobarbitone, pentobarbitone and the metabolites 3′-hydroxybutobarbitone and 3′-hydroxypentobarbitone providing scope for more general pharmacodynamic studies with barbiturates where sample size prrecludes conventional assay.
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