Determination of AVELOX (Moxifloxacin Hydrochloride) Tablets In Dosage Forms Modified With Potentiometer Sensors: A Comparative Analysis

Abstract

Electro-chemical sensors response characteristics of three different electrodes modified with carbon paste (CP), screen printed (SC) and Poly-vinyl chloride(PVC) were fabricated to verify the credibility of drug “AVELOX”, whose generic name is “Moxifloxacin HCl” (AV-MOXH) are traced and calculated. The sensing membranes contain AVELOX (Moxifloxacin HCL) ion association complexes with “sodium tetraphenyl borate” (NaTPB), “Phosphomolybdic acid” (PMA), and “Phosphotungstic acid” (PTA) and “Ammonium Reineckate” (RN) as electro-active materials. All the three electrodes (ICPE, IPVC and ISPE) are subjected to underneath study displays fast, viable and near-Nernstian linear responses above a relative wide-ranging concentration which varies from (1.0×10-6)molL-1 to (1.0×10-2)molL-1 of AV-MOXH at 25°C along with a mono-valent cationic slope. On the basis of calculations and presented data in the paper shows that that the IPVCs modified electrodes, have slope values measured with 7.5mg are (53.2 ± 1.5),(58.2 ± 3.9) and (51.6 ± 2.0) mV decade -1 for NaTPB, PMA and PTA ion pairing reagents respectively. For ISPE modified electrode, the observed slope values are (59.7 ± 2.0) mV decade -1 with 22mg for NaTPB ion pair, (60.1 ± 2.0)mV decade -1 with 16mg for RN ion pair and (58.9 ± 3.2)mV decade -1 with 30 mg for PTA ion pair. Whereas, the obtained value of ICPE electrode altered with 7.5mg NaTPB shows slope calculated at (58.0 ± 2.0)mV decade -1 . The sensors demonstrate good discernment of Av-MOXH from numerous inorganic and organic compounds such as glucose, sucrose, Na+, Ca+,etc. Additionally, the isothermal coefficients along by selectivity coefficients is diagnosed. The modified Screen Printed Electrode sensor appears to be highly sensitive for determination of AV-MOXH. Electrode response was set up to observe their pH dependence range (2-6) for ISPEs and IPVC electrodes and (3-7) pH range for ICPE electrode with varied range of temperature. The short response time, life time validity, recovery and all the method of validation such limit of detection and limit of quantification are estimated. This potentiometric method is suitable for determining AV-MOXH in pharmacological formulations, and the findings obtained are comparable to the “HPLC official method” in terms of agreement. As a result, the postulated potentiometric approach was verified in accordance with IUPAC guidelines.