Abstract
This paper presents an accurate and fast electrochemical method for atorvastatin determination in pharmaceutical products. Two screen-printed sensors, one—carbon based (SPCE) and one based on carbon nanotubes and gold nanoparticles (AuNP-CNT/SPCE) were used during the electrochemical analyses. At all experimental stages, cyclic voltammetry was employed, both for the characterization of the sensors and their electrochemical behavior, and for quantitative determinations. AuNP-CNT/SPCE has showed an extended active area, higher intensity peaks, better reversibility and lower background current than the unmodified sensor. For atorvastatin quantification, a calibration curve has been developed within the 1.2–606.25 µM concentration range. A linearity relation between the current of the anodic peak and concentration has been obtained in the range 1.2–53.33 µMfor both sensors. With the AuNP-CNT/SPCE sensor, low values of limit of detection, LOD (1.92 × 10−7 M) and limit of quantification, LOQ (6.39 × 10−7 M) have been obtained, which demonstrates the feasibility of the method of determining atorvastatin from real samples. Atorvastatin amount has been successfully determined from pharmaceutical products using AuNP-CNT/SPCE. The results were similar to the manufacturer’s specifications regarding the dosage per tablet and to the concentrations obtained by applying the FTIR spectrometric method.
Highlights
IntroductionHyperlipidemia chronic condition conditionmanifested manifestedthrough throughthe the increase triHyperlipidemia is is aa chronic increase of of thethe triglycglyceride levels in blood.The most effective and widely used medication for the treateride levels in blood
This study aims at evaluating the electrochemical behavior of two screen-printed sensors, the former, carbon-based (SPCE) and the latter, based on gold-particles modified carbon nanotubes (AuNP-CNT/screen-printed carbon electrode (SPCE)) and the qualitative and quantitative determination of atorvastatin in a pharmaceutical product
The purpose of the preliminary analyses was the evaluation of the electrochemical behavior of two screen-printed sensors, the former, screen-printed carbon electrode (SPCE) and the latter, based on carbon modified with carbon nanotubes and gold nano- 4 of 15 particles (AuNP-CNT/SPCE)
Summary
Hyperlipidemia chronic condition conditionmanifested manifestedthrough throughthe the increase triHyperlipidemia is is aa chronic increase of of thethe triglycglyceride levels in blood. The most effective and widely used medication for the treateride levels in blood. The most effective and widely used medication for the treatment ment of hyperlipidemia is statins. Atorvastatin fallsininthis thiscategory, category,being being an an inhibitor of hyperlipidemia is statins. Atorvastatin falls inhibitor of of HMG-CoA reductase (an enzyme indispensable for cholesterol biosynthesis in HMG-CoA reductase (an enzyme indispensable for cholesterol biosynthesis inliver) liver)with with significant significantanti-hypercholesterolemic anti-hypercholesterolemiceffects effects[1]. [1].Structurally, Structurally,atorvastatin atorvastatinisisan anaromatic aromatic amide, amide,aamonofluorobenzene monofluorobenzenederivative, derivative,aadihydroxy dihydroxymonocarboxylic monocarboxylicacid acidand andaapyrrole pyrrole derivative. Atorvastatinisisalso alsoaaderivative derivativeof ofheptanoic heptanoicacid acid[2].
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