Abstract
Glial tumors are the largest and danger group of central nervous system tumors. The use of natural products now has been contemplated of exceptional value in the control of cancer. Mushrooms have been used for many centuries, not just as a food, but also to treat many illnesses. Therefore, we aimed to evaluate the effect of exopolysaccharides (EPS) obtained from six different edible mushrooms on the survival of glioma cells. In this study the effects of 0.4, 1, 2, 4 and 6 μg/mL doses of EPSs from six mushroom species Coprinus comatus, Fistulina hepatica, Panus neostrigosus, Laetiporus sulphureus, Polyporus squamosus, and Lenzites betulinus were investigated on the rat glioma cell line (C6) in two different periods by MTT assay. According to our results 0.4 and 1 μg/mL of EPSs from six mushroom species were not effective or less effective, but 2, 4 and 6 μg/mL doses killed glioma cells about 27 to 71 % for 24 hours, 35 to 78 % for 48 hours As a result, these mushroom EPSs showed different cytotoxicity to glioma cells time and dose-dependently. These findings can be suggested that the anti-tumor effects of EPSs can be potential use in clinical applications to treat glioma. Further studies are needed to understand these effects more clearly on glioma.
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