Abstract
Antioxidant activity, anti-aging effects and cytotoxicity activity of cinnamon essential oils from Cinnamomum zeylanicum were investigated in this study. The antioxidant activities of the cinnamon essential oil at the concentrations of 125, 250, 500, and 1000 µg/mL were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2ʹ-azino-bis (3-ethylbenzo-thiazoline-6-sulfonic acid) diammonium salt (ABTS). The inhibitory activities against collagenase, elastase and tyrosinase were evaluated for anti-aging effects. The antioxidant activity determined by DPPH and ABTS assays varied from 4.91 - 28.74% and 4.96 - 50.17%, respectively. In addition, cinnamon essential oil at all concentrations tested (100, 200, 500, and 1000 µg/mL) inhibited tyrosinase activity by 61.68 - 93.12 %, collagenase activity by 2.83 - 30.28 % and elastase activity by 4.37 - 33.92 %. The cytotoxicity activity determined by the diphenyltetrazolium (MTT) assay revealed that the cinnamon essential oil at the concentration less than 100 µg/mL did not exhibit cytotoxicity activity on human fibroblast cells while the percentage of cell viability decreased when exposed to this oil at the concentration higher than 150 µg/mL. These results demonstrated that the cinnamon essential oil has antioxidant, tyrosinase inhibitory, collagenase inhibitory, and elastase inhibitory activities. In addition, cinnamon essential oil at each effective concentration did not show any toxicity when tested on normal human fibroblast cell. Therefore, this essential oil could be a potential candidate for cosmetic and pharmaceutical products.
Highlights
Skin and its accessory assembled to the integumentary system provide the protection for the body
The breakage of collagen and elastin reduces the structure of the dermis and increases the matrix metalloproteinase (MMP) levels that lower the collagen and elastin level (Stevenson et al, 2007; Farage et al, 2008)
Since oxidative stress can be reduced by antioxidant compounds, this study aims to search for natural antioxidant compounds that inhibit skin aging and hyperpigmentation
Summary
Skin and its accessory assembled to the integumentary system provide the protection for the body. Collagenases and elastase, members of the matrix metalloproteinases (MMP) family, can hydrolyze extracellular matrix proteins and lower the collagen and elastin level that cause skin aging. Inhibitors of collagenase, elastase and tyrosinase are important ingredients in cosmetic and medication products to protect skin against hyperpigmentation and aging. Since oxidative stress can be reduced by antioxidant compounds, this study aims to search for natural antioxidant compounds that inhibit skin aging and hyperpigmentation. Many natural products, such as soybean, berry and orange, have been used as beneficial ingredients in several skincare products to promote the protection of skin infections, skin whitening and reducing wrinkles. This study aims to investigate some in vitro biological activities of cinnamon essential oil from Cinnamomum zeylanicum such as antioxidant, tyrosinase inhibitory, collagenase inhibitory, elastase inhibitory, and cytotoxic activities
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