Abstract
Background: Bloodstream infections are considered a significant medical concern associated with high morbidity and mortality rates. Therefore, physicians should be guided to use antimicrobial susceptibility patterns in order to select appropriate empiric antimicrobial agents to treat the patients who suffer from bacteremia. Objective: The present study aimed to determine antimicrobial resistance and susceptibility patterns in isolates collected from bloodstream infections. Materials and Methods: To achieve this, a total of 710 bacterial blood culture isolates were collected from Sina hospital, and then susceptibility patterns to a number of antibiotics were analyzed according to Clinical and Laboratory Standards Institute guidelines. Results: The identified isolates included Staphylococcus aureus 14 (20.6%), Escherichia coli 14 (20.6%), Acinetobacter baumannii 12 (17.6%), Pseudomonas aeruginosa 11 (16.2%), Coagulasenegative Staphylococcus 8 (11.8%), Klebsiella pneumoniae 6 (8.8%), and Enterobacter spp. 3 (4.4%). The total resistance rate to co-trimoxazole, ceftriaxone, ceftazidime, cefotaxime, ofloxacin, gentamicin, ciprofloxacin, levofloxacin, amikacin, and imipenem was 44 (64.7%), 42 (61.8%), 39 (57.4%), 38 (55.9%), 35 (51.51%), 32 (47.1%), 31 (45.6%), 25 (36.8%), and 27 (39.7%), respectively. Finally, the susceptibility rate to amikacin and imipenem was 43 (63.2%) and 41 (60.3%), respectively. Conclusion: In general, A. baumannii strains isolated from blood cultures were resistant to most antibiotics and the greatest sensitivity was observed to gentamicin (58.3%) compared to other antibiotics. Therefore, gentamicin was found as the most effective antibiotic for treating bloodstream infections caused by A. baumannii.
Highlights
Bloodstream infections are considered a significant medical concern associated with high morbidity and mortality rates
Different bacteria are involved in bloodstream infections such as coagulase-negative Staphylococcus, S. aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter spp., and Escherichia coli.[9]
The current study sought to investigate the prevalence of different bacteria isolated from blood cultures in bloodstream infections and their antibiotic susceptibility patterns in patients residing in Sina hospital in Tabriz during (June) 2015(July) 2016
Summary
Bloodstream infections are considered a significant medical concern associated with high morbidity and mortality rates. According to several studies, such infections comprise the major group of infections in some hospitals.[7,8] Different bacteria are involved in bloodstream infections such as coagulase-negative Staphylococcus, S. aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter spp., and Escherichia coli.[9] Each of these strains displays different susceptibility to various antibiotics. The obtained results from an American study revealed that 22% of the fatal bloodstream infections cases were due to E. coli.[10] The most common method for laboratory diagnosis of blood infections is the culture and isolation of bacteria, followed by antimicrobial susceptibility testing.[11] according to the interpretations of the common antibiotic resistance patterns, broad-spectrum antibiotics are prescribed as the first choice for treatment in most suspected septicemia cases.[12] Studying the involved bacteria in blood infections and antibiotic resistance patterns has an important role in empiric treatment. Blood culture is still the best method used for detecting incriminated bacteria in bloodstream infections.[12,13] the current study sought to investigate the prevalence of different bacteria isolated from blood cultures in bloodstream infections and their antibiotic susceptibility patterns in patients residing in Sina hospital in Tabriz during (June) 2015(July) 2016
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