Abstract
Medicinal plants are an indispensable source of new and effective pharmaceutical products. In the study, the biological activities of water extract obtained from the H. rosa-sinensis leaf was determined and its potential for use in the pharmaceutical and cosmetic industries was investigated. Disc diffusion assay and micro-dilution method against clinical origin test microorganisms were used to assess biological activity. The Extract showed a zone of inhibition on the tested bacteria and yeasts in the 6.85 mm to 10.74 mm range. MIC and MBC or MFC values of the Extract was determined as 6.25-12.50 µg/µL and 12.50-50 µg/µL. Then, the cream formulation containing H. rosa-sinensis leaf water extract and/or human milk originated probiotic candidate Limosilactobacillus fermentum MA-7 strain have been developed. The Extract and probiotic containing cream formulations showed variable antibacterial and antifungal effects on the tested clinical originated microorganisms. The highest inhibition zone diameters of Cream + Extract + Probiotic formulation group was obtained against Candida glabrata RSKK 04019 (9.09 mm) and Escherichia coli O157:H7 (9.04 mm). The results indicate that L. fermentum MA-7 and H. rosa-sinensis water extract, alternative to synthetic antimicrobials, may be used as a natural bioactive ingredient in daily personal care and clinical applications in the near future.
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