Abstract
The issue of antibiotic residues in aquaculture products has aroused much concern over the last decade. The residues can remain in food and enter the human body through the food chain, posing great risks to public health. For the safety of foods and products, many countries have issued maximum residue limits and banned lists for antibiotics in aquaculture products. Liquid chromatography tandem mass spectrometry (LC/MS/MS) has been widely used for the determination of trace antibiotic residues due to its high sensitivity, selectivity and throughput. However, considering its matrix effects during quantitative measurements, it has high requirements for sample pre-treatment, instrument parameters and quantitative method. This review summarized the application of LC/MS/MS in the detection of antibiotic residues in aquaculture products in the past decade (from 2010 to 2020), including sample pre-treatment techniques such as hydrolysis, derivatization, extraction and purification, mass spectrometry techniques such as triple quadrupole mass spectrometry and high-resolution mass spectrometry as well as status of matrix certified reference materials (CRMs) and matrix effect.
Highlights
As an ion-pairIn agent and acetonitrile,new a clean-up technique was performed by polyrecent years, increasingly solid-phase extraction sorbents have been applied, meric weak extraction column (Strata the(MWCNTs), result of recovery was from suchcationic as graphene, multiwalled carbon X-CW), nanotubes molecularly imprinted polyto 111%. mers (MIPs) [52,53,54]
Advanced chemical analysis technology is essential for the development of food analysis
LC/MS/MS technology is widely used for antibiotic detection in aquaculture products
Summary
With the rapid development of China’s aquaculture industry, China’s aquaculture production accounts for over 60% of the world’s total [1]. Many countries have gradually introduced maximum residue limits (MRLs) and prohibition lists for veterinary drugs residues in food of animal origin. In 2002, the use of antibiotics such as chloramphenicol, nitrofuran antibiotics and nitroimidazole in food-producing animals was banned in China. The current prohibited antibiotics of aquaculture products in the Chinese standards are basically consistent with those in the EU standards, and both have similar MRLs for most antibiotics Compared with those in the CAC standard, China’s existing veterinary drug residue limits for aquaculture products are more comprehensive. Santos et al [2] summarized the current analytical methods for eight antibiotics in aquaculture fishes, detailing the legal provisions governing antibiotics in different countries and pointing out that multiclass and multiresidue detection is the future trend. The situation of matrix reference material in different countries is discussed as well
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