Determination of anti-oxidative effects of phytogenic substances using a porcine epithelial cell culture model

Abstract

Imbalance of cellular redox homeostasis, accompanied by accumulation of reactive oxygen species (ROS) and oxidative stress, can lead to serious damage of macromolecules, oxidative mediated cell-death, or organ injury. In piglets, disproportionate levels of oxidative stress negatively influence mucosal barrier integrity, formation of tight junctions, and overall absorptive function of the intestine, which all results in a poor animal health state and growth suppression [1, 2]. The discovery of natural feed additives having the potential to combat oxidative stress and its consequences for piglets therefore is of special interest.