Determination of Amitriptyline on a Carbon Nanocomposite Ionic Liquid Electrode

Abstract

This manuscript reports oxidation of amitriptyline at the carbon nanocomposite ionic liquid electrode fabricated using multi-walled carbon nanotubes and the ionic liquid 1-octylpyridinium hexafluorophosphate. The surface morphology of the electrode was characterized by scanning electron microscopy. Differential pulse voltammetry was applied as an analytical procedure for the determination of the sub-micromolar concentration of amitriptyline. Different experimental parameters were optimized. Considering optimized conditions, the proposed electrode represented remarkable sensitivity toward determination of amitriptyline compared to other conventional electrodes and linearity in the range from 5 × 10–8 to 9 × 10–5 was obtained for amitriptyline with the detection limit of 1.9 × 10–8 M. Cyclic voltammetry was applied to obtain information about the reaction mechanism and calculating some kinetic parameters. The oxidation process was irreversible and showed adsorption-controlled behavior. The method was successfully applied for the quantification of amitriptyline in pharmaceuticals forms.