Abstract
We propose a new method for measuring aluminium in bone tissue, using argon plasma emission spectrophotometry. The detection limit in the bone nitric digestion liquid was 0.015 μmol/l (corresponding to 0.0075 μmol/g, i.e. 0.2 μg/g for a tissue sample with 1.0 g wet weight). Within-run CVs were 4.66% and 1.43% for tissues containing 0.15 and 0.64 μmol/g, respectively. Other bone constituents such as calcium, phosphorus, magnesium, sodium, potassium, do not affect aluminium results. Normal values obtained in bone of subjects not suspected of aluminium intoxication were: mean ± SD; 0.09 ± 0.044 μmol/g ( n = 24). In dialysis patients we found a mean bone aluminium content of 0.75 μmol/g for concentrations ranging between 0.16 and 3.38 μmol/g.
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