Abstract
Emepronium bromide, an anticholinergic quaternary ammonium compound, was determined quantitatively in human urine by an ion-pair extraction method. This was constructed by the use of a theoretical approach, and favorable conditions were calculated from extraction constants and constants for side reactions. The principle of choosing selective extraction conditions is discussed on a theoretical basis; it has a general application in drug isolation from samples of such a complicated nature as biological objects. The present method includes extraction of the drug as perchlorate ion pair, purification of the extract, and determination with bromthymol blue. Using a concentration step in the method, a minimum concentration of 0.2 mcg./ml. urine could be determined with an absolute recovery of 98 ± 3%. Utilizing this method, the excretion of emepronium bromide in urine was followed after oral and rectal administration.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
