Abstract
A method has been devised for the determination of N-nitrososarcosine, representative of the group of non-volatile nitrosamines of physiological origin, whereby the nitrosamine is denitrosated with hydrogen bromide to form the volatile nitrosyl bromide. After dehalogenation in a heated converter, the nitrosamine can be determined as nitric oxide by using a chemiluminescence analyser, the response being linear up to at least 200 µg. The limit of detection is below 6 ng, and is therefore much lower than that for the determination of N-nitrososarcosine as inorganic nitrite in solution after denitrosation. A response is also obtained from inorganic nitrite but this can be differentiated from that of N-nitrososarcosine by the use of acetic acid alone, prior to denitrosation with hydrogen bromide in the same solvent.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
