Abstract
A sensitive method is described for the determination of 6-acetylmorphine in urine, to detect the use of heroin by drug addicts participating in a morphine-dispensing experiment. The method is based on an extraction procedure, reaction of the isolated 6-acetylmorphine with excess of morphine to give a highly fluorescent mixed dimer, and determination by normal-phase high-performance liquid chromatography (h.p.l.c.) with fluorescence detection. The calibration graph was linear at low 6-acetylmorphine concentrations and the absolute detection limit was 0.4 ng. In urine samples, 6 μg l −1 of 6-acetylmorphine could be detected. A reversed-phase system is also outlined.
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