Abstract
Rapid and sensitive methods based on LC-MS/MS using positive electrospray ionisation have been developed for the determination of nine 5-nitroimidazoles and their three hydroxylated metabolites in blood serum, egg and muscle samples. The methods use a new type of column based on molecularly imprinted polymer for the cleanup of primary extracts of samples. A validation study was carried out according to criteria (accuracy, linearity, repeatability, reproducibility, ruggedness and specificity) and the requirements of Commission Decision 2002/657/EC. The methods with molecularly imprinted polymers are simple, fast and selective for the extraction of 5-nitroimidazoles from different matrices. They provide high recovery, good reproducibility, clean extracts and low background signals. The decision limits and detection capabilities were lower than the recommended minimum required performance limits in every matrix. These procedures could also be used as screening and confirmatory methods for the monitoring of veterinary drug residues.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
