Abstract
In this study, water-soluble CdTe quantum-dots (QDs) capped with glutathione (GSH) was synthesized. It was found that CdTe QDs could greatly enhance the chemiluminescence (CL) emission from the luminol–KMnO4 system in alkaline medium, and 4nm CdTe QDs was used as catalysts to enhance the reaction sensitivity. The CL intensity of CdTe QDs–luminol–KMnO4 was strongly inhibited in the presence of 2-methoxyestradiol (2-ME) and the relative CL intensity was in linear correlation with the concentration of 2-ME. Based on this inhibition, a novel CL method with a lower detection limit and wider linear range was developed for the determination of 2-ME. The detection limit of plasma samples was 3.07×10−10gmL−1 with a relative standard deviation of 0.24% for 8.0×10−9gmL−1 2-ME. The method was successfully applied for determination of 2-ME in plasma samples. The possible CL reaction mechanism was also discussed briefly.
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