Abstract
A method was developed for the simultaneous determination of 13quinolone(QNs)antibiobtics in swine muscle by ultra performance liquid chromatography tandem mass spectrometry(UPLC-MS/MS).The analytes were extracted from the sample using Na2EDTA-Mcllvaine buffer solution and phosphate buffer with ultrasonic bath and purified by solid-phase extraction(SPE)cartridge.Sample was analyzed in electrospray positive ion and multiple reaction monitoring(MRM)mode.Satisfied recoveries(64.55%—117.62%) of all the drugs are demonstrated in 5.0,50.0and 100.0μg/kg spiked levels with the RSD for intra-day and inter-day of 13analytes less than 14.28%and 12.81%.Limit of detection(LOD)and limit of quantitation(LOQ)are 1.0μg/kg and 5.0μg/kg.The method is sim-ple,accurate,sensitive and suitable for the determination of 13quinolone(QNs)antibiobtics in swine muscle.
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