Abstract
A simple and sensitive HPLC method was developed and validated for the determination of linarin in rat plasma. Plasma samples were carried out by protein precipitation with acetonitrile and separated on a Shim-pack VP-ODS analytical column (250 × 4.6 mm, 5 µm). The calibration curve was linear in the measured range of 20.8-4160 ng/mL and the lower limit of quantification was 20.8 ng/mL for linarin. The validated method was successfully applied to the pharmacokinetic study of linarin in rat plasma after intramuscular administration of monomeric compound and traditional Chinese medicinal preparation - Yejuhua injection.
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