Abstract
The thermodynamics and solubilization behavior of caffeine in non-aqueous binary mixtures of N-methyl-2-pyrrolidone (NMP) and propylene glycol (PG) at temperatures ranged from 293.2 to 313.2 K are measured using a shake-flask method and the obtained solubility data are mathematically represented by using some cosolvency models (e.g. Jouyban-Acree, Jouyban-Acree-van’t Hoff, the mixture response surface, the double log–log and the modified Wilson) and their accuracy is investigated by computation of the mean relative deviations (MRD%) for back-calculated data. The density values of caffeine saturated solutions are determined and represented by Jouyban-Acree equation. Moreover, the apparent thermodynamic parameters of the caffeine dissolution process in the binary mixture of NMP and PG are computed using the Gibbs and van’t Hoff equations at mean harmonic temperature and discussed.
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