Abstract
The objective of this work was to measure and correlate the solubility of lidocaine hydrochloride in eight pure solvents, including ethanol, n-propanol, isopropanol, n-butanol, isobutanol, acetone, methyl acetate, water, and binary mixtures at (291.15 to 331.15) K by using gravimetric method under atmospheric pressure. The results reveal that the solubility of lidocaine hydrochloride increases with increasing temperature in all solvent selected. The modified Apelblat equation, van’t Hoff equation, λh equation, Wilson model and NRTL model were successfully used to correlate the experimental solubility in pure solvents and binary solvent mixtures. In addition, the thermodynamic properties of dissolution of Lidocaine hydrochloride such as Gibbs energy (∆G°sol), molar enthalpy of dissolution (∆H°sol), and molar entropy of dissolution (∆S°sol ) were calculated. Consequently, the experimental solubility and correlation equations can be used as essential data and simulation models in the purification and separation of lidocaine hydrochloride.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
