Determination and correlation of solubility of sarpogrelate hydrochloride in eight solvents at different temperatures

Abstract

In this study, the solubility of sarpogrelate hydrochloride in methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, acetone, acetonitrile, and tetrahydrofuran was determined at temperatures ranging from 288.15K to 308.15K under atmospheric pressure by using a solid-liquid equilibrium method. The obtained experimental solubility data of sarpogrelate hydrochloride were correlated with the modified Apelblat model, Buchowski-Ksiazczak λh model and ideal model. The mole fraction solubility of sarpogrelate hydrochloride in the selected pure solvents increased with the increase in temperature. The maximum mole fraction solubility of sarpogrelate hydrochloride was observed in methanol (1.16×10−2 at 308.15K), followed by that in ethanol (4.76×10−3 at 308.15K), 1-propanol (6.98×10−3 at 308.15K), 1-butanol (4.12×10−4 at 308.15K), acetonitrile (3.13×10−4 at 308.15K), acetone (2.75×10−4 at 308.15K), 2-propanol (1.86×10−4 at 308.15K), and tetrahydrofuran (9.92×10−5 at 308.15K). The correlation and curve fitting results indicated good correlation of the experimental solubility data of sarpogrelate hydrochloride with the modified Apelblat model. Therefore, the experimental solubility and correlation equations established in this study can be useful in the crystallization/purification, preformulation, and formulation stages of sarpogrelate hydrochloride production or testing in laboratories and related industries.