Determinants of Type II Diabetes Mellitus among Tuberculosis Patients in Yangon Region, Myanmar

Abstract

Background: Although having Diabetes Mellitus might adversely affect tuberculosis treatment outcomes and reduce the likelihood of a favorable outcome, studies are still limited to identify many problems related to diabetes mellitus. Objectives: To identify factors influencing Type 2 diabetes mellitus among tuberculosis patients in Yangon region, Myanmar. Methods: A case control study conducted in the Yangon Region of Myanmar. Structured interview questionnaires were used for data collection after obtaining the informed consent. This study included 73 cases (TB patients with DM) and 146 controls (TB patients without DM) who were under tuberculosis treatment in 2023. Unconditional multivariable logistic regressions, crude odds ratios, and Adjusted Odds Ratios (AOR) with 95% confidence intervals and P-values < 0.05 were applied for significant association. Results: Of the 219 TB patients, 112 (51.14%) were male and 107 (48.86%) were female. The study observed that the risk factors of type 2 diabetes mellitus comorbidity among tuberculosis patients were: female TB patients (AOR= 2.84, 95% CI:1.36-5.94), aged 45 years and older (AOR=3.04, 95% CI: 1.45-6.37), who were married (AOR=2.28,95% CI:1.03-5.04), diagnosed by GeneXpert (AOR=2.66, 95% CI:1.22-5.79), those who had a family history of DM (AOR=4.08, 95% CI: 1.94-8.58), and those who had BMI ≥25 (AOR=9.00, 95% CI: 2.71-29.95). Conclusion: Based on findings, women TB patients, TB patients aged 45 years and older, married TB patients, TB patients detected by GeneXpert results, and TB patients with a family history of DM and a higher BMI were strong determinants of having TBDM. Therefore, encouraging health promotion on physical exercise, TB awareness campaign, pre-diabetes and diabetes screening and management among TB patients is crucial for the management of lifestyle and effective measures for the TB and comorbid disease control program.