Determinants of physician assessment of chronic rhinosinusitis disease control using EPOS 2020 criteria and the importance of incorporating patient perspectives of disease control.

Abstract

Herein, we identify CRS manifestations associated with how rhinologists assess CRS control, with a focus on patient perspectives (patient-reported CRS control). Fifteen rhinologists were provided with real-world data from 200 CRS patients. Participating rhinologists first classified patients' CRS control as "controlled", "partly controlled", and "uncontrolled" using 7 CRS manifestations reflecting European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS) CRS control criteria (nasal obstruction, drainage, impaired smell, facial pain/pressure, sleep disturbance, use of systemic antibiotics/corticosteroids in past 6 months, and nasal endoscopy findings) and patient-reported CRS control. They then classified patients' CRS control without knowledge of patient-reported CRS control. Inter-rater reliability, and agreement of rhinologist-assessed CRS control with patient-reported CRS control and EPOS guidelines were determined. CRS control classification with and without knowledge of patient-reported CRS control was highly consistent across rhinologists (κw = 0.758). Rhinologist-assessed CRS control agrees with patient-reported CRS control significantly better when rhinologists have knowledge of patient-reported CRS control than not (κw = 0.736 vs. κw = 0.554, p<0.001). Patient-reported CRS control, nasal obstruction, drainage, and endoscopy findings were most greatly associated with rhinologists' assessment of CRS control. Rhinologists' CRS control assessments weakly agreed with EPOS CRS control guidelines with (κw = 0.529) and without (κw = 0.538) patient-reported CRS control. Rhinologists classified CRS as more controlled than EPOS guidelines in almost 50% of cases. This study directly demonstrates the importance of patient-reported CRS control as a dominant influence on rhinologists' CRS control assessment. Knowledge of patient-reported CRS control may better align rhinologists' CRS control assessments and treatment decisions with patients' perspectives. This article is protected by copyright. All rights reserved.