Determinants of peak oxygen pulse in disorders of glucose metabolism

Abstract

Abstract Funding Acknowledgements Type of funding sources: None. Background/Introduction Oxygen pulse reflects oxygen consumption per heart beat and it provides an information for stroke volume and peripheral oxygen extraction during exercise. Further this, oxygen pulse reported as prognostic for all-cause and cardiovascular mortality. Disorders of glucose metabolism (i.e., prediabetes and overt diabetes mellitus) are important risk factor for cardiovascular disease and might disrupt oxygenation. Purpose We aimed to investigate determinants of peak oxygen pulse in patients with prediabetes and overt diabetes mellitus. Methods Twenty-six patients with disorders of glucose metabolism (mean age: 48,62±7,08 years, HbA1c: 6,51±0,94) were included in the study. Laboratory parameters which very low density lipoprotein cholesterol (VLDL), low and high density lipoprotein (HDL, LDL) levels, HbA1c and C-reactive protein (CRP) levels of participiants were recorded. Patient performed a symptom limited maximal cardiopulmonary test (CPET). Results There was statistically significant negative correlation between oxygen pulse with VLDL (r=-512, p=0,018), CRP (r=-665, p<0.001), waist circumference (r=-471, p=0,015). Based on linear regression analysis, we found that CRP and VLDL explained %40 of variance Oxygen pulse. (R=0.637, R2=0.406, F(2-26). 6.160, p=0.009, constant=0.133). Conclusion(s) CRP and very low density lipoprotein cholesterol levels is independent predictors of oxygen pulse. Management of VLDL levels and inflammation can improve peripheral oxygenization in prediabetes and overt diabetes mellitus.