Determinants of normal macular and retinal nerve fiber layer thickness measured by 3d Oct 2000 - Topcon

Abstract

PURPOSE : To generate the normative data of macular and retinal nerve fiber layer thickness for Bulgarian population using 3D OCT 2000 – Topcon and to evaluate the effects of gender and age on these parameters. MATERIALS AND METHODS : The 131 eyes of 67 healthy individuals aged between 16-71 years, with no ocular disease and best corrected visual acuity of 20/20, were examined using standard scanning protocols. The mean macular and RNFL thickness were evaluated, and the effects of age and gender on these parameters were analyzed. RESULTS : The mean retinal thickness (RT) was 275.4±11.59μm, mean central foveal thickness (CFT) was 241.8±2.01μm, mean central point thickness (CPT) was 213.7±28.64μm. The macular thickness was lowest at the fovea and maximal at the superior inner macula (308.7±13.6 μm). The mean retinal nerve fiber layer (RNFL) thickness was 109.44±9.73μm. The RNFL was thickest in the inferior quadrant (136.13±17.70μm). There was negative but insignificant correlation between macular thickness and volume, and age. The RNFL thickness showed significant negative correlation with age (p=0.03). CFT in females was significantly thinner than in males (p=0.01). CONCLUSIONS : Our findings provide basic data to facilitate macular and RNFL thickness analysis using 3D OCT- 2000. The normative database is important for early diagnosis and evaluation of pathological changes in various retinal diseases and glaucoma. Our results indicate that age and gender must be considered while interpreting macular retinal thickness data.