Determinants of multidrug-resistant tuberculosis in patients attending tertiary care teaching hospital, Vijayapur

Abstract

Background: Multidrug-Resistant Tuberculosis (MDR-TB) has a more rapid course with poor treatment outcomes. Its treatment requires complex multiple 2nd line drug regimens which are longer, more expensive and more toxic Objectives: to identify factors associated with multidrug-resistant tuberculosis in order to identify high risk population who would develop MDR-TB and to suggest possible measures to be taken to reduce MDR-TB incidences in this region. Methods: A structured questionnaire in the vernacular language was used to collect information from study participants and was interviewed privately, and their names were not written on the questionnaire to ensure confidentiality. . Quantitative data were expressed as mean and standard deviation; the qualitative data were expressed as percentages and proportions Results: correlation of HIV positivity was observed in 9(15.3 %) patients. 14(23.7%) patients lived with TB patients earlier. Other diseases (including HIV) were present in 20(33.9%) patients. Excluding HIV, 6 had Diabetes Mellitus, 4 were chronic alcoholics and 1 had psychiatric illness. 12(20.3%) had a history of smoking. The previous TB treatment history of patients undergoing retreatment included site of TB infection being pulmonary in 41(69.5%) and only 2(3.4%) had extrapulmonary TB.27 (62.8%) patients were smear positive during first anti –TB treatment.