Abstract
Tuberculosis is the major global burden of disease contributing about 2% of the global challenges. Poor tuberculosis treatment increased risk of multi-drug resistance tuberculosis occurence. Thus, we aimed to identify determinants of mult-drug resistant tuberclosis in treatment centers of Eastern Amhara, Ethiopia. Facility based unmatched case-control study was employed in East Amhara, Ethiopia. Cases were tuberculosis patients confirmed for mult-drug resistant tuberclosis while controls were tuberculosis patients with confirmed tuberculosis but susceptible to first line drugs. Respondents were selected using simple random sampling technique. Bivariable and multivariable analysis was conducted to identify diterminants at level of statistical significance p < 0.05. We enrolled 450 tuberculosis patients. Rural residents (AOR = 3, 95% CI: 1.4-6.0; p = 0.024), family size greater than five (AOR = 3.7, 95% CI: 1.6-8.6; p = 0.0098), having single room (AOR = 4.1, 95% CI:1.8-9.0; p = 0.027), room without window (AOR = 3.8, 95% CI: 1.6-8.5); p = 0.043), contact history of known mult-drug resistant tuberclosis patient (AOR = 5.1, 95% CI: 2.2-12.0; p = 0.02), history of tuberculosis treatment (AOR = 5.7, 95%CI: 2.6-12.9; p = 0.008), window opening practice (AOR = 3.7, 95% CI: 1.4-9.8; p = 0.005), tuberculosis treatment failure (AOR = 7.3, 95% CI: 5.2-7.8; p = 0.035) and tuberculosis relapse (AOR = 5,95% CI: 1.6-15.2; p = 0.019) were determinants of mult-drug resistant tuberclosis. Socio-demographic (residence, family size), environmental (number of rooms, number of windows in a room, opening window practice) and clinical (history of tuberculosis treatment, treatment failure and having contact with known tuberculosis patient) variables were the identified determinants for increased multi-drug resistance tuberculosis.
Highlights
Tuberculosis is the major global burden of disease contributing about 2% of the global challenges
Tuberculosis (TB) is an airborne disease of the lung and most other body system with varying degrees. It is caused by mycobacterium tuberculosis (Mtb) complex
Miss management of cases onwards contributing for resistivity of ant-TB drugs and people are developing Mult-drug resistant tuberclosis (MDR-TB) and extremely drug-resistant tuberculosis (EXDR-TB)
Summary
Tuberculosis is the major global burden of disease contributing about 2% of the global challenges. We aimed to identify determinants of mult-drug resistant tuberclosis in treatment centers of Eastern Amhara, Ethiopia. Conclusions: Socio-demographic (residence, family size), environmental (number of rooms, number of windows in a room, opening window practice) and clinical (history of tuberculosis treatment, treatment failure and having contact with known tuberculosis patient) variables were the identified determinants for increased multi-drug resistance tuberculosis. TB was an ancient disease of the poor that affects humankind since 400 years ago It became still the major global burden of disease (GBD) contributing about 2 % of the global challenges [2]. TB was the second leading cause of death next to acquired immune deficiency virus (AIDS) [3] It was the fourth highest burden of disease contributor in Ethiopia [4]. Ethiopia was the seventh TB burdened country in the world [5]
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