Abstract
Background: Proton Pump Inhibitors (PPIs) are the first line agents in the treatment of gastro-esophageal reflux disease (GERD). The efficiency and safety profile of PPIs have driven to its over-utilization and the protracted recipients are targets to its long-term adverse such as chronic kidney disease (CKD), Clostridium difficile infection and community-acquired pneumonia etc. Therefore, the study was intended to explore the PPI utilization patterns in GERD patients in an Indian tertiary-care hospital. Materials and Methods: A cross-sectional study was carried out at the Department of Gastroenterology, in a private tertiary care hospital, Bangalore, for a period of six months. The objective of the study was to identify the risk factors of GERD and prescribing trends of proton pump inhibitors in GERD patients. Results: Among the 139 patients diagnosed with GERD, 66% were males. GERD was found to be more prevalent in the age group of 25-44 years. The GERD patients reported a relationship between the severity of disease and the following risk factors, namely, Smoking, OR: 0.446, alcoholism, OR: 1.26, BMI>24.9, OR:1.13 and mixed diet, OR:0.486). Rabeprazole (36.4%) was the commonly prescribed PPI. PPI combination therapy was prescribed in 56.11% of patients, followed by single therapy in 39.5% patients. Conclusion: Creating awareness among the clinicians and patients on appropriate use of PPIs can reduce the additional economic burden and improve the health-related quality of life. Focusing on risk factors to identify preventive measures will help in decreasing the incident rate of GERD.
Highlights
Proton pump inhibitors (PPIs) are widely prescribed classes of medications, used in the treatment of gastrointestinal (GI) disorders
The gastro-esophageal reflux disease (GERD) patients reported a relationship between the severity of disease and the following risk factors, namely, Smoking, odds ratio (OR): 0.446, alcoholism, OR: 1.26, BMI>24.9,OR:1.13 and mixed diet, OR:0.486
Focusing on risk factors to identify preventive measures will help in decreasing the incident rate of GERD
Summary
Proton pump inhibitors (PPIs) are widely prescribed classes of medications, used in the treatment of gastrointestinal (GI) disorders. They act by inhibiting the H+/K+-adenosine triphosphatase (ATPase), or proton pump, located in the highly acidic lumen of parietal cells (Blume et al, 2006). Protracted usage of PPIs can lead to its long term adverse effects such as chronic kidney disease (CKD), Clostridium difficile infection (CDI), community-acquired pneumonia (CAP), osteoporosis etc (Gikas et al, 2014, Ito et al, 2010, Heidelbaugh et al, 2012). The efficiency and safety profile of PPIs have driven to its over-utilization and the protracted recipients are targets to its long-term adverse such as chronic kidney disease (CKD), Clostridium difficile infection (CDI) and community-acquired pneumonia (CAP) etc. The study was intended to explore the PPI utilization patterns in GERD patients in an Indian tertiary-care hospital
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