Abstract
Diminished FPIS is proposed to be a metabolic marker in the diagnosis and follow up of prediabetes in trials of intervention to prevent IDDM. However, data are scarce regarding the determinants of insulin secretion in normal children. This study aimed to investigate the relationship of physical fitness (FP) and body composition (BC) to in-vivo insulin secretion during a hyperglycemic clamp in 12 (6M/6F) healthy adolescents (Tanner II-IV). Age was 14.0±0.6 yrs and body mass index (BMI) 19.1±0.5 kg/m2. BC was assessed by bioelectric impedance plethysmography; PF by maximum oxygen consumption (VO2max) during progressive bicycle ergometry; and FPIS (0-10 min) and SPIS (10-120 min) during a 120 min hyperglycemic clamp (+125 mg/dl above fasting plasma glucose). FPIS was 75.1±9.0 μu/ml and SPIS 105.0±9.6 μu/inl. FPIS and SPIS were inversely correlated with VO2max (r=−.60 p=0.02, r=-0.70 p=0.005), with no relationship to BC or % body fat. % body fat showed an inverse relationship (r=−0.53 p-0.04) to insulin sensitivity index. Males had significantly lower % BF, higher VO2max and higher insulin sensitivity compared with females, but no difference in FPIS and SPIS.
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