Abstract
IntroductionTuberculosis (TB) remains a worldwide public health problem with 8.6 millions of new cases and 1.3 millions of death annually. Despite the progress recorded in fighting against this disease in the recent years, Africa is still not on the track to achieve the objective to reduce by half the death rate due to this disease by 2015.MethodsA case-control study was conducted on data of patients admitted for tuberculosis between 1996 and 2011 in the Diagnostic and Treatment Center of Baleng. Cases were patients who died from any cause during anti tuberculosis treatment. Logistic regression model was used to identify factors associated to death.ResultsIn 4201 patients treated during the study period, 3245 (77.24%) were included in the study. The mean age was 35.9 (SD 14.2) and male represent 62.2% (CI 60.6- 63.9) of them. At the end of the follow up, 2883 patients were successfully treated, 362 died during treatment and 132 (36.5%) deaths occurred during the first two months of TB treatment. HIV positive status, Extra-pulmonary TB, sputum smear-negative pulmonary TB and male sex were significant independent risk factors of death with adjusted odds ratio of 4.8 (CI 3.2- 7.4); 3.0 (CI 1.6- 5.4); 2.7 (CI 1.7- 4.4) and 1.5 (CI 1.0- 2.3) respectively.ConclusionThe mortality rate of TB patients undergoing TB treatment remains high. Studies are needed to identify and test efficient interventions of mortality reduction among TB patients in resource limiting settings.
Highlights
Tuberculosis (TB) remains a worldwide public health problem with 8.6 millions of new cases and 1.3 millions of death annually
In the process of identifying interventions to reduce tuberculosis burden, there is a need to identify factors associated to death among TB patients
At the end of patients' follow up, they are classified into six groups[1]: cured; Completed treatment; Failed; Defaulted; Transferred and Died
Summary
Tuberculosis (TB) remains a worldwide public health problem with 8.6 millions of new cases and 1.3 millions of death annually. With 8.7 million new cases and a specific mortality of 1.4 million cases of death in 2011, tuberculosis remains a major public health problem in the world [1]. It has been observed that the global TB incidence rate is falling in most parts of the world [6] Despite these progresses, TB remains the second leading cause of death from an infectious disease worldwide [1]. According to WHO, additional efforts are needed in African Region which is currently not on track to achieve the mortality and prevalence targets [1] These efforts should include the identification of the determinants of death among patients undergoing anti tuberculosis treatment. This study had as objective to identify, amongst patients diagnosed with TB between 1996 and 2011in Baleng TB Diagnostic and Treatment Center (DTC) of West Cameroon, factors associated to TB death
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
