Abstract
Hand, foot, and mouth disease (HFMD) is a common disease caused by human enterovirus (HEV). The symptoms and signs of infection among children typically present with vesicular exanthema on the soles of their feet, the palms of their hands and in their mouths, causing discomfort and feeding difficulties. The disease is caused by mainly Coxsackie virus A16 (CVA16) serotype. It has recently been associated with EV-71 serotype which can also cause outbreak and mortality. Currently the data of HFMD cases in Indonesia is not available yet therefore this study aims to identify and determine the distribution of HFMD cases in Indonesia from the outbreak. HFMD can be identified by RT-PCR that recognize PAN-EV gene in the first place and has to be continued to EV-71 in VP1 area. Besides using PCR, we use isolation method using tissue cultures which are RD and 293 cell linesrom. From 48 suspected cases were received in virology lab CBBTH, NIHRD. 26 out of 48 cases (54%) were caused by enterovirus and 3 out of 26 were EV-71 (6,25%). The HFMD cases distribute in all group of ages and sex but children under five is the most susceptible. Key words: HFMD, Enterovirus, Outbreak, EV71
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