Abstract
We are developing a novel counting detector with high spatial and ultrahigh temporal resolution for 2D single molecule detection in solution. It is based on an image intensifier optically coupled to a position sensitive detector for photon-bursts. An electric trigger signal taken from the image intensifier provides sub-nanosecond temporal resolution. The detector has the following features: true single photon counting with a quantum efficiency of approximately 20% (photo cathode), spatial resolution approximately 200 X 200 pixels, temporal resolution approximately 100 ps, and a maximum count rate of several million counts per second. The design of the detector is inspired by the technique of time correlated single photon counting (TCSPC). It allows the simultaneous determination of the position of fluorescing molecules and their fluorescence lifetime.
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