Detection of urinary modified nucleosides by a bulk acoustic wave MIP sensor – Results and future work

C De Schutter,F Théodoro,A Pruvost,D Rebière,S Dulong,J.-L Lachaud,R Vidal,F Levi,H Hallil,A Krstulja,P Favetta,C Junot,V Roy,R Delépée,N Lebal,V Raimbault,C Dejous,N Omar Aouled,L.A Agrofoglio

doi:10.1016/j.irbm.2014.02.009

Detection of urinary modified nucleosides by a bulk acoustic wave MIP sensor – Results and future work

C De Schutter, F Théodoro + Show 17 more

https://doi.org/10.1016/j.irbm.2014.02.009

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Journal: IRBM	Publication Date: Mar 20, 2014
Citations: 18

Affiliation: Institut de Biologie et Technologies, CEA Saclay, Atomic Energy and Alternative Energies Commission, University of Bordeaux, Institut Polytechnique de Bordeaux, French National Centre for Scientific Research, Inserm, University of Paris-Sud, Institut Polytechnique de Paris, Merck (France), University of Orléans

#Sensitive Mass Spectrometry Method #Bulk Acoustic Wave + Show 8 more

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Abstract

This paper presents an overview of the main actions and projects of the ANR TECSAN “CancerSensor” during the 2011–2014 period. The project aims to develop and validate a quantitative, non-invasive therapeutic tool to detect selected urinary modified nucleosides as biomarkers of colorectal cancer chemotherapy and to monitor in fine the efficiency of the chemotherapy. A methodology has been developed to generate a bulk acoustic wave molecularly imprinted polymer sensor (SAW-MIP) for the detection of various nucleosides and nucleotides of interest. A rapid and sensitive mass spectrometry method has been also developed.

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