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Abstract
The lack of efficient detection techniques has so far prevented ultrasound-modulated optical tomography from achieving maturity. By applying a quantum spectral filter based on spectral-hole burning, one modulation sideband of the ultrasound-modulated diffuse photons can be efficiently selected while the DC and the other sidebands are blocked. This technique features a large etendue as well as the capability of processing numerous speckles in parallel. It is also immune to speckle decorrelation, potentially allowing real-time in vivo imaging. Both theory and experiments are presented.
Highlights
In biological tissues, noninvasive imaging using non-ionizing optical radiation [1] is highly desirable because optical contrast provides sensitive tissue discriminations
By applying a quantum spectral filter based on spectral-hole burning, one modulation sideband of the ultrasound-modulated diffuse photons can be efficiently selected while the DC and the other sidebands are blocked
We present the theoretical aspect of this novel technique in the context of Ultrasound-modulated optical tomography (UOT) and the experimental observations
Summary
Noninvasive imaging using non-ionizing optical radiation [1] is highly desirable because optical contrast provides sensitive tissue discriminations. A confocal Fabry-Perot interferometer (CFPI) [10] was employed to filter one sideband of the ultrasound-modulated photons while blocking the DC and the other modulation sidebands This technique still suffers from a relatively small etendue, it is improved over that of the single detector. To overcome the detection difficulty in UOT, we have recently employed spectral-hole burning (SHB) as a front-end absorptive filter, which efficiently extracts the ultrasoundmodulated photons with a superior etendue [18] This optical absorptive filter transmits one modulation sideband of the speckles while blocking the DC and the other sidebands, as in CFPI, allowing the transmitted speckles to be incoherently integrated. We present the theoretical aspect of this novel technique in the context of UOT and the experimental observations
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